Deep Vein Thrombosis United States Incidence 2020-2040 in Patients and Limbs and by Anatomic Territory

Deep vein thrombosis (DVT) is a blood clot that occurs in the deep veins, most commonly in the legs, or lower extremity DVT (LEDVT). While the majority of DVT occurs in the lower limbs, the deep veins in the upper extremities can also thrombose (UEDVT).

The primary purpose of this research is to estimate the U.S. incidence of DVT in the 2020-2040 period. Estimates are in 5-year increments. Incidence in patients and limbs is provided for DVT in the lower extremities as well as the upper extremities.

Available data on the number of cases of DVT primarily focuses on venous thromboembolism (VTE), which includes pulmonary embolism (PE) plus/minus DVT, as well as DVT alone.

Consequently, estimates began with VTE incidence and calculated DVT according to its percentage of the total number of VTE cases. DVT is defined as DVT only, plus DVT that occurs with PE.

All percentages employed for the calculations are based on the conclusions reached after comprehensive literature reviews. These percentages are applied to the U.S. Census Bureau’s 2020-2040 population projections for the population ages 18 and older.

Anatomic location is an important factor in the consequences of DVT including the risk and severity of post-thrombotic syndrome (PTS), recurrence rates and the probability of an associated PE.

Estimates are included for proximal and distal LEDVT, as well as for the incidence of iliofemoral and femoropopliteal DVT and iliofemoral DVT with no calf or popliteal involvement.

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