The Sage Group

China – Peripheral Artery Disease and Critical Limb Ischemia Prevalence and Incidence 2017

Estimates for peripheral artery disease (PAD) and critical limb ischemia (CLI) in China are sparse to nonexistent. This report contains a comprehensive analysis of the current prevalence and incidence of PAD and CLI in China.

The prevalence of diabetes is rapidly increasing worldwide. Diabetes has grown at a faster rate in Asia than in Western countries, reaching epidemic proportions in the region. Over the last several decades, the number of diabetics in China has risen significantly, reflecting the combination of urbanization, dietary changes, decline in physical activity, growing obesity, especially abdominal obesity, and the aging population.

Employing the Diabetes Method, the 2015 prevalence of PAD and CLI is estimated for China, and the prevalence of each is projected for the 2015-2035 period. PAD and CLI incidence estimates are also included for 2015-2035. PAD prevalence in Chinese diabetics as well as in the general population is assessed and compared with THE SAGE GROUP estimates.

The Chinese epidemiology of hypertension, chronic kidney disease and smoking and the impact of these risk factors on PAD are detailed. PAD and CLI prevalence and incidence are also estimated for 2015-2035 employing these three key risk factors.

The final range of PAD and CLI estimates for 2015-2035 is based on calculations by the Diabetes Method and hypertension.

The number of symptomatic and asymptomatic Chinese PAD cases is estimated for 2015-2035 with specific estimates for intermittent claudication (IC) and critical limb ischemia. Since only a fraction of IC and CLI patients are diagnosed and treated, the number of CLI and IC patients diagnosed and treated is included. These estimates represent the current actual market for interventional therapies.

Asymptomatic patients represent the market for cardiovascular risk factor modification therapies.

Prevalence is defined as the number of new and old cases of PAD and CLI. Incidence is defined as the annual number of new cases of these diseases.

The Diabetes Method is an age- and glucose-based method to estimate atherosclerotic lower limb disease. Employing U.S. Census Bureau’s International Data Base (IDB), the population is segmented into 3 age groups.

Within each of these age groups, the population is divided into two glucose states: Diabetic (diagnosed and undiagnosed) and Nondiabetic (normal glucose and prediabetes). PAD is calculated according to the percentage prevalence in each glucose state. Then the prevalence of CLI is calculated in those with PAD by glucose status.

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