India – Peripheral Arterial Disease, Thromboangiitis Obliterans & Critical Limb Ischemia Epidemiology and Markets

Population-based research on the epidemiology of critical limb ischemia (CLI) in India remains almost non-existent.

According to conventional wisdom, the vast majority of CLI in India is caused by Buerger’s Disease, also known as Thromboangiitis Obliterans (TAO). Atherosclerotic lower limb disease, known as peripheral arterial disease (PAD) or peripheral vascular disease (PVD) is considered a “Western Disease” and is generally thought to be rare in the Indian subcontinent.

As concluded by the India analysis, this is not the case. Afflicting over 20 million citizens, atherosclerotic PAD is many times more prevalent in India than TAO. Compared with PAD, TAO is relatively uncommon in India. Both PAD and atherosclerotic CLI represent major and significantly underestimated problems for the Indian economy and healthcare system.

India contains a comprehensive analysis of the 2008 prevalence of peripheral artery disease (PAD), thromboangiitis obliterans (TAO) and critical limb ischemia by cause.

The number of people with PAD, TAO and CLI are projected for the 2008-2015 periods. Market analysis includes the number of patients and limbs diagnosed and treated for each disease category.

Prevalence is defined as the number of new and old cases of peripheral artery disease, thromboangiitis obliterans and critical limb ischemia.

Peer-reviewed research on the incidence and prevalence of diabetes, peripheral artery, disease, TAO and critical limb ischemia in India is reviewed, analyzed and assessed. In addition, the Indian data is compared to published research on incidence and prevalence in the United States and Western Europe.

Peripheral Artery Disease-related CLI prevalence is calculated based on The Diabetes Method, which was previously validated, in CLI Volume I. The Diabetes Method begins with segmenting the population of each country by age and glucose status, calculating the prevalence of peripheral arterial disease in each glucose category and finally the prevalence of critical ischemia by PAD and glucose status.

Thromboangiitis obliterans prevalence is calculated using a recent study in Bangladesh. CLI caused by TAO is estimated based on an analysis of published research.

In addition to diabetes, the report also analyzes the prevalence of the major risk factors for PAD, TAO & CLI; tobacco use, hypertension, dyslipidemia in the Indian population.

An overview of Indian demographics as well as the economic and healthcare system is also provided.

This report is the third in a series published on CLI. The first report focused on CLI epidemiology in the United States; the second focused on CLI in the 15 major countries of Western Europe.

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