The Sage Group

The Cost of Critical Limb Ischemia

The costs of chronic diseases represent a significant burden on the U.S. healthcare system. With the ageing population and the increasing prevalence of diabetes, cardiovascular diseases have become widely prevalent and account for the use of a rising percentage of scarce healthcare resources.

While the costs of other cardiovascular diseases, such as myocardial infarction and stroke, have been extensively studied, data on the economic burden of critical limb ischemia (CLI) remains sparse. It is only in the past few years that research has been published on the costs of CLI.

This report estimates the 2018 cost of CLI in the U.S. Three types of cost estimates are provided: CLI inpatient treatment costs, CLI plus comorbid cardiovascular costs and all-cause costs of CLI.

The research data on which these estimates are based is reviewed and the cost calculation methods are explained. All cost estimates begin with THE SAGE GROUP’S 2015 CLI prevalence estimate. In order to compare costs from U.S. studies reporting data in different years, all cost data is translated into 2018 dollars.

Selected non-U.S. CLI research is included in the analysis. However, CLI cost estimates are based on costs in U. S. studies only. This reflects the fact that costs cannot be compared across countries because of differences in clinical practice, reimbursement systems and prices.

A major portion of the report is devoted to a discussion and analysis of research on the key factors responsible for CLI costs. Among others, these include major amputation, treatment at more severe disease stages, comorbid cardiovascular disease and diabetes and readmissions. Notably, most of the factors driving up costs are either modifiable or preventable.

The analysis of the variables responsible for CLI costs also contains estimates for the costs of specific components such as major amputation, major adverse cardiac events (MACE), major adverse leg events (MALE) and the cost of CLI with diabetes compared with CLI without diabetes.

Price: $5,800

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